House remembers clues about a patient’s illness and tries to begin to piece it together. Meanwhile House’s friendship with Wilson is very rocky due to the memories of the bus accident that almost changed their lives .
House becomes confused and bloody after getting into a bus accident. House can not remember very much leading to the accident. He believes that there was a patient that was deadly ill before the crash happened. House has head injures and is in pain but tries to solve the puzzle.
House believes that one of his favorite soap opera actors has a serious illness after he sees the actor on TV. House decides to step in and the actor and the team conclude there is nothing wrong.
House believes his patient was wrongfully diagnosed by the E.R. and has a bigger problem than what was diagnosed. House questions the patient trying to diagnose his patient.